Anti-tumor activity of the methanolic extracts of Salvia menthifolia

Revista Brasileira de Farmacognosia

Giovina Fiore²  Paola Massarelli²  Maurizio Sajeva¹  Gian Gabriele Franchi² 

[1] ,University of Siena Department of Neurological, Neurosurgical and Behavioral Sciences Section of Pharmacology G. Segre,Italy

关键词: apoptosis glioblastoma;    Salvia menthifolia;    sage;   

DOI  :  10.1590/S0102-695X2011005000220

来源: SciELO

【 摘 要 】

In the present research we investigated the anti-proliferative activity of Salvia menthifolia Ten. (formerly Salvia menthaefolia), Lamiaceae, on a glioblastoma cell line, since up to date poor therapeutic results have been reported for treatment of malignant glioblastoma. Methanol extracts from different anatomical parts of S. menthifolia were tested on DBTRG-05MG cell line by MTT assay. The most active primary stems extract was also evaluated for apoptosis induction. Results confirmed the anti-tumor property of all the organs and demonstrated that the primary stems extract induced apoptosis after 4 h with the highest values of DNA fragmentation after 6 to 24 h. Some extracts were also HPLC analyzed for polyphenols, althought activities could be due also to other constituents and to synergistic interactions. Rosmarinic acid, caffeic acid, luteolin-7-O-glucosyde and quercitrin were found in all the extracts. The good performance revealed for S. menthifolia towards this extremely aggressive human glioblastoma cell line confirms that the genus Salvia is a natural source of anti-tumor agents though there are great differences among the various species.

【 授权许可】

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