Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis

Revista Brasileira de Farmacognosia

Hesham R. El-seedi²  Rehan El-shabasy¹  Hanem Sakr¹  Mervat Zayed¹  Asmaa M. A. El-said¹  Khalid M. H. Helmy¹  Ahmed H. M. Gaara¹  Zaki Turki¹  Muhammad Azeem²  Ahmed M. Ahmed¹  Loutfy Boulos¹  Anna-karin Borg-karlson²  Ulf Göransson¹ 

[1] ,Royal Institute of Technology KTH Department of Chemistry ,Sweden

关键词: anti-schistosomiasis;    Asparagus stipularis;    Asparagaceae;    triterpene glycoside;   

DOI  :  10.1590/S0102-695X2012005000004

来源: SciELO

【 摘 要 】

Bioassay-guided isolation using an in vitro assay testing for anti- schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 µg/mL concentration.

【 授权许可】

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