Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Revista Brasileira de Farmacognosia

Juliana M. C. Silva²  Nednaldo Dantas-santos²  Dayanne L. Gomes²  Leandro S. Costa²  Sara L. Cordeiro²  Mariana S. S. P. Costa²  Naisandra B. Silva¹  Maria L. Freitas¹  Katia Castanho Scortecci¹  Edda L. Leite¹  Hugo A. O. Rocha² 

[1] ,Universidade Federal do Rio Grande do Norte Departamento de Bioquímica ,Brazil

关键词: anticoagulant activity;    antioxidant activity;    seagrass;    sulfated galactans;   

DOI  :  10.1590/S0102-695X2011005000199

来源: SciELO

【 摘 要 】

A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.

【 授权许可】

CC BY-NC-ND   
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