Revista Brasileira de Farmacognosia | |
Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla | |
Marcos José Salvador2  João Ernesto De Carvalho1  Alberto Wisniewski-jr1  Candida A. L. Kassuya1  Élide P. Santos1  Dilamara Riva1  Maria Élida Alves Stefanello1  | |
[1] ,Universidade Estadual de Campinas Instituto de Biologia Departamento de Biologia Vegetal,Brazil | |
关键词: Casearia lasiophylla; Salicaceae; essential oil; germacrene D; β-caryophyllene; antitumor; | |
DOI : 10.1590/S0102-695X2011005000073 | |
来源: SciELO | |
【 摘 要 】
The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro againstU251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), β-caryophyllene (14.7%), δ-cadinene (6.2%), and α-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 µg/mL), with exception of NCI-H460 cell line (TGI 191.31 µg/mL). The highest activity was observed against UACC-62 (TGI 7.30 µg/mL), and K562 (TGI 7.56 µg/mL) cell lines. The observed activity could be related to high content of germacrene D and β-caryophyllene, compounds known as cytotoxic.
【 授权许可】
CC BY-NC-ND
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