Evaluation of acute toxicity of babassu mesocarp in mice

Revista Brasileira de Farmacognosia

Elizabeth S. B. Barroqueiro¹  Fernanda S. B. Barroqueiro¹  Mayara T. Pinheiro¹  Márcia C. G. Maciel¹  Priscila S. Barcellos¹  Lucilene A. Silva¹  Adelson S. Lopes¹  Flávia R. F. Nascimento¹  Rosane N. M. Guerra¹ 

[1] ,Universidade Federal do Maranhão,Brazil

关键词: babassu;    blood biochemistry;    mesocarp;    oral acute toxicity;    Orbignya phalerata;   

DOI  :  10.1590/S0102-695X2011005000121

来源: SciELO

【 摘 要 】

The safety of babassu mesocarp (Orbignya phalerata Mart., Arecaceae), which exhibited anti-inflammatory and antithrombotic activities, was evaluated by determining the potential acute toxicity in mice. A lyophilized ethanol extract of babassu mesocarp (BME) was administered to C3H/HePas mice (10/group) in a single dose of 1000, 3000 and 5000 mg/kg, by gavage. General behavior adverse effects and mortality were determined for up to fourteen days. Selected biochemical parameters including glucose, triacylglyceride, cholesterol, urea, alkaline phosphatase and creatinine were determined by colorimetric assay. The heart, liver, spleen, kidneys and brain were weighted and evaluated macro and microscopically. The median lethal dose (LD50) of BME was greater than 5000 mg/kg. No behavior or body weight alterations were detected after the treatment. The acute treatment with BME has no effect on macroscopic and microscopic aspect of examined organs. Instead, BME increased the alkaline phosphatase and reduced the urea concentration in all groups. A significant increase on triacylglyceride was detected in the group BME1000. In conclusion, the acute treatment with high doses of BME can affect some biochemical parameters with a long lasting effect, although any change was detected at tissue level or body and organ weight.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License