Bioassay-guided evaluation of central nervous system effects of citronellal in rodents

Revista Brasileira de Farmacognosia

Mônica S. Melo²  Marilia T. De Santana²  Adriana G. Guimarães²  Rosana S. Siqueira²  Damião P. De Sousa²  R. V. Santos²  Leonardo R. Bonjardim²  Adriano A. S. Araújo²  Alexandre S. C. Onofre²  Julianeli T. Lima¹  Jackson R. G. S. Almeida¹  Lucindo J. Quintans-júnior² 

[1] ,Universidade Federal de Sergipe Departamento de Fisiologia ,Brazil

关键词: anticonvulsant activity;    citronellal;    depressant activity;    monoterpenes;   

DOI  :  10.1590/S0102-695X2011005000124

来源: SciELO

【 摘 要 】

The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABA A receptor. These results suggest a possible CNS depressant and anticonvulsant activities.

【 授权许可】

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