Chemical composition and biological screening of Capsella bursa-pastoris

Revista Brasileira de Farmacognosia

Clara Grosso²  Juliana Vinholes²  Luís R. Silva²  Paula Guedes De Pinho¹  Rui F. Gonçalves²  Patrícia Valentão²  Anna K. Jäger¹  Paula B. Andrade² 

[1] ,Universidade do Porto Faculdade de Farmácia Departamento de Química,Portugal

关键词: acetylcholinesterase inhibition antibacterial activity;    antioxidant activity;    Capsella bursa-pastoris;    metabolic profile;   

DOI  :  10.1590/S0102-695X2011005000107

来源: SciELO

【 摘 要 】

Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and β-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH•, O2•- and LOO•), being most effective against •NO (EC25 0.20 µg/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

【 授权许可】

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