Modulation of drug resistance in Staphylococcus aureus by extract of mango (Mangifera indica L., Anacardiaceae) peel

Revista Brasileira de Farmacognosia

Susy Mary Souto De Oliveira²  Vivyanne S. Falcão-silva¹  José P. Siqueira-junior¹  Maria José De Carvalho Costa¹  Margareth De Fátima F. De Melo Diniz² 

[1] ,Universidade Federal da Paraíba Centro de Ciências da Saúde Produtos Naturais e Sintéticos BioativosJoão Pessoa PB ,Brazil

关键词: Mangifera indica L;    mango peel;    ethanol extract;    Staphylococcus aureus;    modulation of drug resistance;    efflux pump inhibitor;   

DOI  :  10.1590/S0102-695X2011005000014

来源: SciELO

【 摘 要 】

In an ongoing project to evaluate natural compounds isolated from by-products or wastes from vegetables and fruits (edible plants) as modulators of antibiotic resistance, ethanol extract from mango peel was investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance to norfloxacin, erythromycin and tetracycline. The minimum inhibitory concentrations (MIC) of the antibiotics were determined by the micro dilution assay in the absence and in the presence of sub-inhibitory mango peel extract concentration. Although the extract did not display relevant antibacterial activity (MIC>2048 µg/mL), it modulated the activity of antibiotics, i.e. in combination with antibiotics (at 512 µg/mL), a four-fold reduction in the MIC values for tetracycline and erythromycin was observed. The results presented here indicates that mango peel could serve as a source of potential adjuvant of antibiotics which add value to this mango by-product.

【 授权许可】

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