期刊论文详细信息
Revista Brasileira de Farmacognosia
Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits
Maria Goretty P. R. Ferreira2  Anderson M. Kayano1  Izaltina Silva-jardim2  Tatiany O. Da Silva2  Juliana P. Zuliani2  Valdir A. Facundo1  Leonardo De A. Calderon2  Alexandre De Almeida-e-silva2  Pietro Ciancaglini1  Rodrigo G. Stábeli2 
[1] ,Fundação Oswaldo Cruz Instituto de Pesquisas em Patologias Tropicais de Rondônia Porto Velho RO ,Brazil
关键词: Piper tuberculatum;    Piperaceae;    3-(3;    4;    5-trimethoxyphenyl) propanoic acid;    Leishmania amazonensis;    leishmanicidal activity;    Piper tuberculatum Jacq.;    Piperaceae;    ácido 3;    4;    5-trimetoxi-dihidrocinâmico;    Leishmania amazonensis;    atividade leishmanicida;   
DOI  :  10.1590/S0102-695X2010005000033
来源: SciELO
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【 摘 要 】

Leishmanicidal activity of the 3-(3,4,5-trimethoxyphenyl) propanoic acid (TMPP) isolated from EtOH extracts of the Amazonian Piper turbeculatum Jacq. fruits was evaluated in vitro using Leishmania amazonensis promastigotes. The TMPP was assayed at concentrations of 1600 to 6.25 µg/mL for 24, 48, 72 and 96 h. Promastigotes viability was analyzed and the IC50 of TMPP was 145 µg/mL.

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