Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits

Revista Brasileira de Farmacognosia

Maria Goretty P. R. Ferreira²  Anderson M. Kayano¹  Izaltina Silva-jardim²  Tatiany O. Da Silva²  Juliana P. Zuliani²  Valdir A. Facundo¹  Leonardo De A. Calderon²  Alexandre De Almeida-e-silva²  Pietro Ciancaglini¹  Rodrigo G. Stábeli² 

[1] ,Fundação Oswaldo Cruz Instituto de Pesquisas em Patologias Tropicais de Rondônia Porto Velho RO ,Brazil

关键词: Piper tuberculatum;    Piperaceae;    3-(3;    4;    5-trimethoxyphenyl) propanoic acid;    Leishmania amazonensis;    leishmanicidal activity;    Piper tuberculatum Jacq.;    Piperaceae;    ácido 3;    4;    5-trimetoxi-dihidrocinâmico;    Leishmania amazonensis;    atividade leishmanicida;   

DOI  :  10.1590/S0102-695X2010005000033

来源: SciELO

【 摘 要 】

Leishmanicidal activity of the 3-(3,4,5-trimethoxyphenyl) propanoic acid (TMPP) isolated from EtOH extracts of the Amazonian Piper turbeculatum Jacq. fruits was evaluated in vitro using Leishmania amazonensis promastigotes. The TMPP was assayed at concentrations of 1600 to 6.25 µg/mL for 24, 48, 72 and 96 h. Promastigotes viability was analyzed and the IC50 of TMPP was 145 µg/mL.

【 授权许可】

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