Evaluation of antimicrobial, antioxidant and phototoxic activities of extracts and isolated compounds from Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae

Revista Brasileira de Farmacognosia

Pierre André De Souza²  Carmelita Gomes Silva²  Barbara Rosa Pimentel Machado²  Nanci Camara De Lucas²  Gilda Guimarães Leitão¹  Elis Cristina Araújo Eleutherio¹  Gisela Maria Dellamora Ortiz¹  Leslie C Benchetrit¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Química Departamento de Química OrgânicaRio de Janeiro RJ ,Brazil

关键词: Stachytarpheta cayennensis;    antioxidant;    antimicrobial;    phototoxicity;    arylpropanoid glycosides;    betulinic acid;    Stachytarpheta cayennensis;    antioxidante;    antimicrobial;    fototoxicidade;    arilpropanoide glicosilado;    ácido betulínico;   

DOI  :  10.1590/S0102-695X2010005000042

来源: SciELO

【 摘 要 】

Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, plant extract, is a Brazilian medicinal plant externally used in folk medicine for purulent ulcers, skin lesions and internally for inflammations, fever, renal disorders and atherosclerosis. S. cayennesis was studied to identify potential bioactive compounds that may justify their therapeutic use against skin lesions and atherosclerosis. The antioxidant, antimicrobial and phototoxicity capacities of the crude ethanolic extract, fractions and isolated compounds from roots of S. cayennesis were evaluated through in vivo and in vitro tests. Strains of Saccharomyces cerevisiae, an eukaryotic cell model, were used to assess both the phototoxicity and the capacity to protect against the lethal oxidative stress caused by menadione and hydrogen peroxide. The extract, fractions and the two major isolated compounds, verbascoside and betulinic acid, of S. cayennensis were able to increase the tolerance and decrease the lipid peroxidation of S. cerevisiae to reactive oxygen species (ROS). The antioxidant activity was also evaluated by scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH•). Verbascoside exhibited a moderate antimicrobial activity against Streptococcus pyogenes, S.epidermidis and Staphylococcus aureus. Neither the ethanolic extract nor fractions showed phototoxicity, indicating that the S. cayennensis extract is safe for use in the treatment of skin lesions and as an active cosmetic ingredient.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License