Vasorelaxant effect of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, dichloromethane extract on rat mesenteric artery

Revista Brasileira de Farmacognosia

Ítalo J. A. Moreira²  Maria P. N. Moreno¹  Maria F. G. Fernandes¹  João B. Fernandes¹  Flávia V. Moreira²  Ângelo R. Antoniolli²  Márcio R.v. Santos² 

[1] ,Universidade Federal de Sergipe Departamento de Fisiologia São Cristóvão SE ,Brazil

关键词: Hyptis fruticosa;    dichloromethane extract;    vasorelaxant effect;    mesenteric artery;    rats;    Hyptis fruticosa;    extrato diclorometano;    efeito vasorelaxante;    artéria mesentérica;    ratos;   

DOI  :  10.1590/S0102-695X2010005000003

来源: SciELO

【 摘 要 】

Vasorelaxant effect of Hyptis fruticosa dichloromethane extract (HFDE) on isolated rings of rat mesenteric artery was evaluated in this study. In intact rings, HFDE (0.1-3000 µg/mL) induced concentration-dependent vasorelaxations (Emax = 119±14%; n = 6) of phenylephrine tonus that were not modified after endothelium removal (Emax = 116±6%; n = 6), after KCl 20 mM (Emax = 135±9%; n = 6) or in rings pre-contracted with KCl 80 mM (Emax = 125±4%; n = 6). In endothelium denuded rings, HFDE (300 or 1000 µg/mL) inhibited contractions induced by CaCl2 (maximal inhibition = 25±7% and 95±1%; respectively). Furthermore, HFDE promoted an additional vasorelaxation (15±3%; n = 7) after maximal response of 10 µM nifedipine (78±3%; n = 7). In conclusion, HFDE induces vasorelaxant effect through an endothelium-independent pathway, which appears to be due in major part to inhibition of the Ca2+ influx through voltage-operated Ca2+ channels.

【 授权许可】

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