Anticonvulsant effect of the ethanol extract of Caesalpiniapulcherrima (L.) Sw., Fabaceae, leaves

Revista Brasileira de Farmacognosia

Dinesh Kumar¹  Jitender Singh¹  Anupama Baghotia¹  Sunil Kumar¹ 

[1] ,Kurukshetra University Institute of Pharmaceutical Sciences Kurukshetra Haryana ,India

关键词: Caesalpinia pulcherrima;    ethanol extract;    anticonvulsant effect;    maximal electroshock;    pentylenetetrazole;    Caesalpinia pulcherrima;    extrato etanólico;    efeito anticonvulsivante;    máximo eletrochoque;    pentlenetetrazol;   

DOI  :  10.1590/S0102-695X2010005000014

来源: SciELO

【 摘 要 】

In this study, ethanol extract of Caesalpinia pulcherrima (L.) Sw., Fabaceae, leaves (CPEE) was investigated for anticonvulsant effect against maximal electroshock (MES) and pentylenetetrazole (PTZ) induced seizures in rats and mice at dose levels 200 and 400 mg/kg, i.p. respectively. Diazepam (3 mg/kg, i.p.) was used as a standard anticonvulsant drug for comparison. CPEE was found to be safe up to the dose of 4000 mg/kg in mice, when administered intraperitoneally. The extract at 400 mg/kg dose produced significant (p<0.01) anticonvulsant effect w.r.t. control against PTZ-induced clonic seizures. In MES-induced seizure model, there were no significant alterations in the onset as well as duration of hind limb extension seizures as compared to control at a dose of 200 mg/kg when administered intraperitoneally. However, the extract (CPEE, 400 mg/kg i.p.) significantly (p<0.01) delayed the onset as well as decreased the duration of hind limb extension seizures (HLES) as compared to control. However, the extract, CPEE, percentage protection of the animals was increased at higher dose (200 mg/kg) in both the models. The results of the study suggest that ethanol extract of Caesalpinia pulcherrima (L.) Sw. leaves possess anticonvulsant effect.

【 授权许可】

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