Chemopreventive activity of phenylalanine against damage mutagenic prompted by the acute administration of cyclophosphamide in pregnant and non-pregnant mice using the micronucleus test

Revista Brasileira de Farmacognosia

Mariana De Oliveira Mauro²  João Renato Pesarini²  Priscila Lumi Ishii²  Ariane Fernanda Da Silva¹  Rodrigo Juliano Oliveira² 

[1] ,Centro Universitário Filadélfia Departamento de Biomedicina e Nutrição Centro de Estudo em Nutrição e Genética ToxicológicaLondrina PR ,Brasil

关键词: Phenylalanine;    antigenotoxic;    cyclophosphamide;    pregnant;    Fenilalanina;    antigenotóxico;    ciclofosfamida;    prenhes;   

DOI  :  10.1590/S0102-695X2010000300008

来源: SciELO

【 摘 要 】

This study aimed to evaluate the quimiopreventive ability of phenylalanine. We used pregnant and non-pregnant female mice divided into the following groups: G1-PBS, (0.1 mL/kg b.w); G2, cyclophosphamide (35 mg/kg p.c.-i.p.); G3 and G4, phenylalanine (150 and 300 mg/kg b.w respectively-v.o.) and G5 and G6, association between the two doses of phenylalanine and cyclophosphamide, respectively. The peripheral blood samples were taken at T0, before the administration of any drug test and / or vehicles, also at T24 and T48 where the collections were made 24 and 48 h after administration of cyclophosphamide, respectively. A general analysis has found that, for the group of non-pregnant female, the antimutagenic evaluation showed reduction percentages of damage of 57.24% and 31.64% for G5 and G6, respectively, at T24, and 29.32% and 24.13% for G5 and G6, respectively, at T48. Antimutagenic pregnant animals in the 24 h quimiopreventive efficiency shown only for the lower dose (G5) and the percentages of reduction were 43.25% in G5 and G6 at 18.47%. At T48 the harm-reduction percentages were 44.67% and 37.76% for G5 and G6, respectively.

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