Antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens

Revista Brasileira de Farmacognosia

Marcele A. Ferreira²  Tatiane C. Carvalho²  Izabel C. C. Turatti¹  Niege A. J. C. Furtado²  Carlos H. G. Martins²  Norberto P. Lopes¹  Wilson R. Cunha²  Antonio E. M. Crotti² 

[1] ,Universidade de Franca Núcleo de Pesquisas em Ciências Exatas e Tecnológicas Franca SP ,Brazil

关键词: Aegiphila sellowiana;    antimicrobial activity;    GC-MS;    oral pathogens;    Lamiaceae;    Aegiphila sellowiana;    antividade antimicrobiana;    CG-EM;    patógenos orais;    Lamiaceae;   

DOI  :  10.1590/S0102-695X2010000200018

来源: SciELO

【 摘 要 】

The antimicrobial activity of Aegiphila sellowiana Cham., Lamiaceae, against oral pathogens is reported. The Minimal Inhibitory Concentrations (MICs) for inhibiting the microorganisms growth were determined using the broth microdilution method from the CLSI M7-A7 protocol. Chlorhexidine was used as the positive control. The ethanol crude extract of the aerial parts of A. sellowiana exhibited activity against the microorganisms tested in this work; however, the activity decreased after partition with n-hexane, dichloromethane, and ethyl acetate. Among the tested fractions, the n-hexane fraction was found to be the most effective against the evaluated oral pathogens. GC-MS analysis of this latter fraction revealed that fatty acids esters, steroids, and aliphatic sesquiterpene hydrocarbons are its major constituents. These compounds may be responsible for the activity of the n-hexane fraction, but other chemical constituents of the dichloromethane, ethyl acetate, and hydroalcoholic fraction may potentialize their activities in the crude extract.

【 授权许可】

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