Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and Meliaceae active plant extracts

Revista Brasileira de Farmacognosia

Ana C. Leite²  Artur Placeres Neto²  Alessandra R. P. Ambrozin²  João B. Fernandes²  Paulo C. Vieira²  Maria F. Das G. F. Da Silva²  Sérgio De Albuquerque¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP ,Brazil

关键词: Myrsinaceae;    Meliaceae;    trypanocidal activity;    flavonoids;    limonoids;    Myrsinaceae;    Meliaceae;    atividade tripanocida;    flavonoides;    limonoides;   

DOI  :  10.1590/S0102-695X2010000100002

来源: SciELO

【 摘 要 】

The activity of crude extracts of three Rapanea species (Myrsinaceae) and Cipadessa fruticosa (Meliaceae) was evaluated in vitro against the trypomastigote forms of Trypanosoma cruzi. Thirty-three extracts from different organs of these species were assayed and eleven of them showed significant activity (lysis % >50). The fractionation of an active extract from branches of R. lancifolia (99.5%) led to the isolation of two flavonoids: quercetin and taxifolin, which have weak trypanocidal activity. Additionally, one active extract from fruits of C. fruticosa (97.7%) afforded mexicanolide limonoids: cipadesin, mexicanolide, febrifugin and cipadesin A, that were slightly active on T. cruzi. Moreover, other two flavonoids (flavone and 7-methoxyflavone), previously assayed against T. cruzi, were isolated from the hexane extract from branches of C. fruticosa (100%). The results presented here suggest that the plants evaluated could be a source of new active compounds against T. cruzi.

【 授权许可】

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