Antinociceptive, anti-inflammatory and diuretic properties of Polygonum barbatum (L.) Hara var. barbata

Revista Brasileira de Farmacognosia

M. Abdul Mazid²  Bidyut K. Datta¹  Lutfun Nahar¹  S. A. M. Khairul Bashar¹  Sitesh C. Bachar¹  Satyajit D. Sarker¹ 

[1] ,University of Dhaka Department of Pharmaceutical Chemistry Dhaka,Bangladesh

关键词: Polygonum barbatum var. barbata;    Polygonaceae;    antinociceptive;    anti-inflammatory;    diuretic;    animal model;    Polygonum barbatum var. barbata;    Polygonaceae;    analgesic;    antiinflammatório;    diurético;    modelo animal;   

DOI  :  10.1590/S0102-695X2009000500017

来源: SciELO

【 摘 要 】

The antinociceptive, anti-inflammatory and diuretic properties of the extracts of P. barbatum (L.) Hara var. barbata, Polygonaceae, at the doses of 200 and 400 mg/kg body weight, were evaluated in mice/rat models using, respectively, the acetic-acid-induced writhing method, the carrageenan-induced edema test and the Lipschitz method. In the acetic-acid-induced writhing test in mice, all extracts displayed a dose dependent analgesic effect. The most potent analgesic activity was observed with the petroleum ether extract at the dose of 400 mg/kg body weight with an inhibition of writhing response 46.8% compared to 62.2% for the positive control aminopyrine. Petroleum ether extract at the dose of 400 mg/kg body weight also displayed the highest levels of anti-inflammatory activity after 2 h with the 39.3% inhibition of paw edema, and this effect was better than the effect observed by the conventional anti-inflammatory agent phenylbutazone (maximum inhibition of 38.3% after 4 h). All extracts increased urine volume in a dose-dependent manner, and the ethyl acetate extract showed a significant level of diuresis comparable to that of the standard diuretic agent furosemide.

【 授权许可】

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