Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

Revista Brasileira de Farmacognosia

Mariana P. Leite²  Jaime Fassin Jr.²  Eliane M. F. Baziloni²  Reinaldo N. Almeida¹  Rita Mattei²  José R. Leite² 

[1] ,Universidade Federal de São Paulo Departamento de Psicobiologia São Paulo SP ,Brazil

关键词: Essential oil;    Citrus aurantium;    Rutaceae;    orange oil;    anxiety;    inhalation;    plus-maze;    Óleo essencial;    Citrus aurantium;    Rutaceae;    óleo de laranja;    ansiedade;    inalação;    labirinto em cruz elevado;   

DOI  :  10.1590/S0102-695X2008000500003

来源: SciELO

【 摘 要 】

The orange essential oil (OEO) and its components obtained from Citrus aurantium L. (Rutaceae) has been attracting interest due to its sedative and relaxing actions. In the present study, rats previously exposed to OEO at the concentrations of 1.0%; 2.5% and 5.0%, w/w, by inhalation during 7 minutes in acrylic boxes were evaluated in two anxiety models: elevated plus maze (EPM) and open-field. The OEO at the concentration of 2.5% increased both the time of the animals in the open arms of the EPM and the time of active social interaction in the open-field being longer than that of the diazepam group (1.5 mg/kg i.p). In conclusion, the decrease in the level of emotionality of the animals observed in the two experimental models suggests a possible central action, which is in agreement with the phytochemical profile of the oil under study, since it showed the presence of limonene (96.24%) and mircene (2.24%), components with a well-known depressant activity on the central nervous system.

【 授权许可】

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