Assessment of effects of a formula used in the traditional Chinese medicine (Buzhong Yi Qi Wan) on the morphologic and osmotic fragility of red blood cells

Revista Brasileira de Farmacognosia

Tania S. Giani²  Severo De Paoli²  Giuseppe A. Presta²  Adalgisa I. Maiworm²  Sebastião D. Santos-filho²  Adenilson S. Fonseca¹  Mario Bernardo-filho² 

[1] ,Universidade Federal do Rio Grande do Norte Centro de Ciências da Saúde Natal RN ,Brazil

关键词: Buzhong Yi Qi Wan;    morphology;    osmotic fragility;    red blood cell;    Buzhong Yi Qi Wan;    fragilidade osmótica;    hemácias;    morfologia;   

DOI  :  10.1590/S0102-695X2007000400005

来源: SciELO

【 摘 要 】

Buzhong Yi Qi Wan (BYQW) is a combination of some medicinal herbs widely used in traditional Chinese medicine to treat blood, spleen and stomach disorders. Morphometric analysis and osmotic fragility assay have been used to evaluate changes on membrane integrity of red blood cells. The aim of this work was to evaluate the effect of an aqueous BYQW extract on the morphology and osmotic fragility of red blood cells. Blood samples were treated with BYQW extract, quantitative/qualitative morphological analysis and osmotic fragility assay were carried out against control groups treated with saline. The data obtained indicated no modification on morphology but osmotic fragility assay suggested a significant (p<0.05) increasing of hemolysis in red blood cells isolated from blood treated with aqueous BYQW extract. In conclusion, the aqueous BYQW extract could affect the membrane integrity decreasing the osmotic resistance but without altering the shape of red blood cells.

【 授权许可】

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