Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats

Revista Brasileira de Farmacognosia

Fatima Torrico²  Mariana Cepeda²  Geraldine Guerrero²  Fidel Melendez²  Zuleima Blanco²  Dilsia J. Canelón²  Beth Diaz²  Reinaldo S. Compagnone¹  Alírica I. Suárez² 

[1] ,Universidad Central de Venezuela Facultad de Farmacia Caracas,Venezuela

关键词: Croton cuneatus;    streptozotocin;    blood glucose;    antihyperglycemic effect;    Croton cuneatus;    estreptozotocina;    açúcar no sangue;    efeito antihiperglicémico;   

DOI  :  10.1590/S0102-695X2007000200005

来源: SciELO

【 摘 要 】

Aqueous extract of the stem barks of Croton cuneatus Klotz (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocin(STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/kg i.p.) were separately administered to groups of fasted normal and diabetic rats. Plasma glucose concentration, cholesterol and changes in body weight were evaluated. The chronic intraperitoneal (i.p.) administration of the extract for 22 days was found to induce significant reduction in blood glucose level. A comparison was made between the action of the aqueous extract of C. cuneatus and the reference standard drug glibenclamide. The results of this experimental animal study indicate that this plant has an antidiabetic activity in hiperglycaemic rat models.

【 授权许可】

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