Air pollution and children's health: sickle cell disease

Cadernos de Saúde Pública

Silvia Maria De Macedo Barbosa¹  Sylvia Costa Lima Farhat¹  Lourdes Conceição Martins¹  Luiz Alberto Amador Pereira¹  Paulo Hilário Nascimento Saldiva¹  Antonella Zanobetti¹  Alfésio Luís Ferreira Braga¹ 

关键词: Air Pollution;    Sickle Cell Disease;    Emergency Medical Services;    Poluição do Ar;    Anemia Falciforme;    Serviços Médicos de Emergência;    Contaminación del Aire;    Anemia de Células Falciformes;    Servicios Médicos de Urgencia;   

DOI  :  10.1590/0102-311X00013214

来源: SciELO

【 摘 要 】

The hallmarks of sickle cell disease are anemia and vasculopathy. The aim of this study was to assess the association between air pollution and children's emergency room visits of sickle cell patients. We adopted a case-crossover design. Daily counts of children's and adolescents' sickle cell disease emergency room visits from the pediatric emergency unit in São Paulo, Brazil, were evaluated from September 1999 to December 2004, matching by temperature, humidity and controlling for day of the week. Interquartile range increases of the four-day moving averages of PM10, NO2, SO2, CO, and O3 were associated with increases of 18.9% (95%CI: 11.2-26.5), 19% (95%CI: 8.3-29.6), 14.4% (95%CI: 6.5-22.4), 16,5% (95%CI: 8.9-24.0), and 9.8% (95%CI: 1.1-18.6) in total sickle cell emergency room visits, respectively. When the analyses were stratified by pain, PM10 was found to be 40.3% higher than in sickle cell patients without pain symptoms. Exposure to air pollution can affect the cardiovascular health of children and may promote a significant health burden in a sensitive group.

【 授权许可】

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