Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Cadernos de Saúde Pública

Daniela Massierer²  Denis Martinez²  Sandra Costa Fuchs²  Paulo P. Pellin¹  Márcio S. Garcia¹  Ana Luisa Zacharias¹  Isadora F. Antunes¹  Marco V. Wainstein²  Leila Beltrami Moreira²  Jorge Pinto Ribeiro²  Flavio Danni Fuchs² 

[1] ,Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Porto Alegre,Brasil

关键词: Coronary Artery Disease;    Obstructive Sleep Apnea;    Questionnaires;    Doença da Artéria Coronariana;    Apnéia do Sono Tipo Obstrutiva;    Questionários;   

DOI  :  10.1590/S0102-311X2012000800011

来源: SciELO

【 摘 要 】

Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis > 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.

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