A systematic review of mercury ototoxicity

Cadernos de Saúde Pública

Ana Cristina Hiromi Hoshino²  Heloisa Pacheco Ferreira¹  Olaf Malm¹  Renata Mamede Carvallo¹  Volney Magalhães Câmara² 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Estudos em Saúde Coletiva Rio de Janeiro,Brasil

关键词: Mercury;    Toxicity;    Hearing;    Dizziness;    Mercúrio;    Toxicidade;    Audição;    Tontura;   

DOI  :  10.1590/S0102-311X2012000700003

来源: SciELO

【 摘 要 】

Mercury is neurotoxic, and numerous studies have confirmed its ototoxic effect. However, the diagnosis and follow-up of mercury exposure require understanding the pathophysiology of the chemical substance. Based on a systematic literature review, this study aimed to demonstrate whether mercury is ototoxic and to analyze its mechanism of action on the peripheral and central auditory system, in order to contribute to the diagnosis and follow-up of exposure. This was a systematic review of studies published on the effects of mercury exposure on the auditory system. The full text of the studies and their methodological quality were analyzed. The review identified 108 studies published on the theme, of which 28 met the inclusion criteria. All the articles in the analysis showed that mercury exposure is ototoxic and produces peripheral and/or central damage. Acute and long-term exposure produces irreversible damage to the central auditory system. Biomarkers were unable to predict the relationship between degree of mercury poisoning and degree of lesion in the auditory system.

【 授权许可】

CC BY   
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