Estimates of HIV-1 incidence based on serological methods: a brief methodological review

Cadernos de Saúde Pública

Mariza Gonçalves Morgado²  Francisco Inácio Bastos¹ 

[1] ,Fundação Oswaldo Cruz Instituto Oswaldo Cruz Rio de Janeiro,Brasil

关键词: HIV-1;    HIV Infections;    Incidence;    HIV-1;    Infecções por HIV;    Incidência;   

DOI  :  10.1590/S0102-311X2011001300002

来源: SciELO

【 摘 要 】

The paper reviews the serological methods employed in the estimation of HIV incidence based on cross-sectional studies, as well as the main findings from studies carried out in Brazil that have used such methods. Each method is briefly described, as well as their advantages and limitations. The different methods are also analyzed as a set of complementary but sometimes contradictory strategies under permanent criticism and review, still far from a gold standard. Finally, an additional question % central to the accurate monitoring of the AIDS epidemic using such methods % is discussed: whether the different methods should or should not be adjusted. The debate is open and controversy should be viewed as an unavoidable consequence of a very dynamic research field, informed by the progress in sciences as diverse as epidemiology, biostatistics, mathematical modeling and different branches of basic science, such as immunology, virology, and molecular biology.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License