PAH biomarkers for human health risk assessment: a review of the state-of-the-art

Cadernos de Saúde Pública

Sérgio Silveira Franco¹  Adelaide Cássia Nardocci¹  Wanda Maria Risso Günther¹ 

[1] ,Universidade de São Paulo Faculdade de Saúde Pública São Paulo,Brasil

关键词: Aromatic Polycyclic Hydrocarbons;    Biological Markers;    Risk Assessment;    Hidrocarbonetos Policíclicos Aromáticos;    Marcadores Biológicos;    Avaliação de Risco;   

DOI  :  10.1590/S0102-311X2008001600009

来源: SciELO

【 摘 要 】

Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.

【 授权许可】

CC BY   
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