Rationale for the study of the human sex ratio in population studies of polluted environments

Cadernos de Saúde Pública

John Jarrell¹ 

[1] ,University of Calgary Faculty of Medicine Department of Obstetrics & GynecologyAlberta,Canada

关键词: Sex Ratio;    Reproduction;    Infertility;    Endocrine Disruptors;    Razão de Masculinidade;    Reprodução;    Infertilidade;    Desreguladores Endócrinos;   

DOI  :  10.1590/S0102-311X2002000200007

来源: SciELO

【 摘 要 】

The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.

【 授权许可】

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