Lung cancer and arsenic exposure in drinking water: a case-control study in northern Chile

Cadernos de Saúde Pública

Catterina Ferreccio²  Claudia Gonzalez Psych²  Vivian Milosavjlevic Stat²  Guillermo Marshall Gredis¹  Ana María Sancha¹ 

[1] ,Grupo para el Desarrollo de la Investigación en SaludSantiago,Chile

关键词: Lung Neoplasms;    Environmental Exposure;    Arsenic;    Neoplasias de Pulmón;    Exposición Ambiental;    Arsénico;   

DOI  :  10.1590/S0102-311X1998000700021

来源: SciELO

【 摘 要 】

In some Chilean cities, levels of arsenic (As) in drinking water reached 800 µg/L between 1950 and 1970, while current levels are 40 µg/L. To evaluate the causal role of this exposure in lung and bladder cancers, we conducted a case-control study in Regions I, II, and III of the country. From 1994 to 1996, cases diagnosed as lung cancer and two hospital controls were entered in the study; one control was a patient with a cancer, while the other was a patient without cancer, both conditions unrelated to As. Controls were matched with cases by age and sex. A standard survey containing questions about residence, employment, health history, was administered to study subjects. Data on As concentrations in water were obtained from records of the municipal water companies. A total of 151 lung cancer cases and 419 controls (167 with cancer and 242 without cancer) were enrolled. Median level of lifetime As exposure was significantly higher among cases, with a clear dose-response relationship between mean As exposure levels, with an OR (95% CI) of: 1, 1.7 (0.5-5.1), 3.9 (1.2-13.4), 5.5 (2.2-13.5), and 9.0 (3.6-22) for strata one to five respectively. This study provides new evidence that As in drinking water can cause internal cancers and gives an estimate of the form of this relationship.

【 授权许可】

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