Resveratrol plays important role in protective mechanisms in renal disease - mini-review

Jornal Brasileiro de Nefrologia

Guilherme Albertoni¹  Nestor Schor¹ 

关键词: angiotensin II;    endothelin-1;    polyphenols;    protective agents;    angiotensina II;    endotelina-1;    polifenóis;    substâncias protetoras;   

DOI  :  10.5935/0101-2800.20150015

来源: SciELO

【 摘 要 】

Resveratrol (RESV) is a polyphenolic compound found in various plants, including grapes, berries and peanuts, and its processed foods as red wine. RESV possesses a variety of bioactivities, including antioxidant, anti-inflammatory, cardioprotective, antidiabetic, anticancer, chemopreventive, neuroprotective, renal lipotoxicity preventative, and renal protective effects. Numerous studies have demonstrated that polyphenols promote cardiovascular health. Furthermore, RESV can ameliorate several types of renal injury in animal models, including diabetic nephropathy, hyperuricemic, drug-induced injury, aldosterone-induced injury, ischemia-reperfusion injury, sepsis-related injury, and endothelial dysfunction. In addition, RESV can prevent the increase in vasoconstrictors, such as angiotensin II (AII) and endothelin-1 (ET-1), as well as intracellular calcium, in mesangial cells. Together, these findings suggest a potential role for RESV as a supplemental therapy for the prevention of renal injury.

【 授权许可】

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