Corticotherapy response in primary IgA nephropathy

Jornal Brasileiro de Nefrologia

Natália Novaretti²  Gyl Eanes Barros Silva¹  Roberto Silva Costa¹  Miguel Moysés Neto¹  Osvaldo Merege Vieira Neto¹  Elen Almeida Romão¹  Eduardo Barbosa Coelho¹  Márcio Dantas¹ 

[1] ,USP FMRP Hospital das Clínicas

关键词: glomerular filtration rate;    glomerulonephritis;    IgA;    proteinuria;    steroids;    glomerulonefrite por IgA;    glucocorticoides;    proteinúria;    taxa de filtração glomerular;   

DOI  :  10.5935/01012800.20130005

来源: SciELO

【 摘 要 】

INTRODUCTION: Some beneficial effects from long-term use of corticosteroids have been reported in patients with IgA nephropathy. OBJECTIVE: This retrospective study aimed to evaluate the outcome of proteinuria and renal function according to a protocol based on a 6-month course of steroid treatment. METHOD: Twelve patients were treated with 1 g/day intravenous methylprednisolone for 3 consecutive days at the beginning of months 1, 3, and 5 plus 0.5 mg/kg oral prednisone on alternate days for 6 months (treated group). The control group included 9 untreated patients. RESULTS: Proteinuria (median and 25th and 75th percentiles) at baseline in the treated group was 1861 mg/24h (1518; 2417 mg/24h) and was 703 mg/24h (245; 983) and 684 mg/24h (266; 1023) at the 6th (p < 0.05 vs. baseline) and 12th months (p < 0.05 vs. baseline), respectively. In the control group the proteinuria was 1900 mg/24h (1620; 3197) at baseline and was 2290 mg/24h (1500; 2975) and 1600 mg/24h (1180; 2395) at the 6th and 12th months, respectively (not significant vs. baseline). When compared with the control group, the treated group showed lower proteinuria (p < 0.05) during the follow-up and a higher number of patients in remission (p < 0.05) at the 6th and 12th months. Renal function did not change during the follow-up and the adverse effects were mild in most of the patients. CONCLUSION: The 6-month course of steroid treatment was effective in reducing proteinuria during the 12 months of the follow-up, and was well-tolerated by most of the patients.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License