Correlation between interleukin-18promoter -607C/A polymorphism and susceptibility to ischemic stroke

Brazilian Journal of Medical and Biological Research

Jian-xia Lu¹  Zhong-qian Lu¹  Shao-lan Zhang¹  Juan Zhi¹  Zheng-ping Chen¹  Wan-xiang Wang¹ 

关键词: IL-18;    Polymorphism;    Ischemic stroke;    Correlation;   

DOI  :  10.1590/1414-431X20132850

来源: SciELO

【 摘 要 】

Single nucleotide polymorphisms in the promoter region ofinterleukin-18 (IL-18), an inflammatory cytokine, have been linked to susceptibility to many diseases, including cancer and immune dysfunction. Here, we explored the potential association between theIL-18 -607C/A (rs1946518) promoter region polymorphism and susceptibility to ischemic stroke (IS). This locus was amplified from peripheral blood samples of 386 IS patients (cases) and 364 healthy individuals (controls) by the polymerase chain reaction with sequence-specific primers. Significant differences were observed by the χ2 test in the -607C/A (rs1946518) genotype and allele frequencies between cases and controls (P < 0.05). Furthermore, after excluding for age, gender, smoking status, and hypertension, logistic regression indicated that IS susceptibility of -607C carriers increased 1.6 times (OR = 1.601, 95%CI = 1.148-2.233, P = 0.006) compared to -607A carriers. Additionally, similar increases in IS risk were noted for male patients or patients less than 65 years old. In conclusion,IL-18 -607C/A (rs1946518) promoter polymorphism is associated with IS susceptibility, and the C allele may confer increased IS risk.

【 授权许可】

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