MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients

Brazilian Journal of Medical and Biological Research

E.r.f. Siqueira²  C.p.m.s. Oliveira²  M.l. Correa-giannella¹  J.t. Stefano²  A.m. Cavaleiro¹  M.a.h.z. Fortes¹  M.t.c. Muniz¹  F.s. Silva¹  L.m.m.b. Pereira¹  F.j. Carrilho² 

[1] ,Universidade de São Paulo Faculdade de Medicina LIM-07São Paulo SP ,Brasil

关键词: Hepatitis C;    Steatosis;    Fibrosis;    Microsomal transfer protein;   

DOI  :  10.1590/S0100-879X2011007500160

来源: SciELO

【 摘 要 】

The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson’s disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one G allele versus 34.3% of the patients with fibrosis grade 1+2 (OR = 1.8; 95%CI = 1.3-2.3). Logistic regression analysis with steatosis as the dependent variable identified genotypes GG+GT as independent protective factors against steatosis (OR = 0.4, 95%CI = 0.2-0.8; P = 0.01). The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients.

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