Gender-dependent effects of aging on the kidney

Brazilian Journal of Medical and Biological Research

A.l. Gava²  F.p.s. Freitas²  S.s. Meyrelles²  I.v. Silva¹  J.b. Graceli¹ 

[1] ,Universidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências Fisiológicas Laboratório de Transgenes e Controle Cardiovascular

关键词: Sexual dimorphism;    Renal function;    Aging;    Cardiovascular disorders;    Sex hormones;   

DOI  :  10.1590/S0100-879X2011007500101

来源: SciELO

【 摘 要 】

It is well known that the kidney plays an important role in the development of cardiovascular diseases such as hypertension. The normal aging process leads to changes in kidney morphology, hemodynamics and function, which increase the incidence of cardiovascular events in the elderly population. These disturbances are influenced by several factors, including gender. In general, females are protected by the effects of estrogens on the cardiorenal system. Several studies have demonstrated the beneficial effects of estrogens on renal function in the elderly; however, the relationships between androgens and kidney health during one’s lifetime are not well understood. Sex steroids have many complex actions, and the decline in their levels during aging clearly influences kidney function, decreases the renal reserve and facilitates the development of cardiovascular disorders. Therefore, in this review, we discuss the cellular, biochemical, and molecular mechanisms by which sex hormones may influence renal function during the aging process.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License