Prenatally programmed hypertension: role of maternal diabetes

Brazilian Journal of Medical and Biological Research

G.n. Gomes¹  F.z. Gil¹ 

[1] ,Universidade Federal de São Paulo Departamento de Fisiologia Disciplina Fisiologia Renal e TermometabologiaSão Paulo SP ,Brasil

关键词: Hypertension;    Maternal diabetes;    Renal impairment;    Sodium retention;   

DOI  :  10.1590/S0100-879X2011007500109

来源: SciELO

【 摘 要 】

Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of diabetes among pregnant women. In this review, we discuss how renal and extrarenal mechanisms participate in the genesis of hypertension induced by a diabetic status during fetal development.

【 授权许可】

CC BY   
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