期刊论文详细信息
Brazilian Journal of Medical and Biological Research
Effect of hormone replacement on exercise cardiopulmonary reserve and recovery performance in subclinical hypothyroidism
M.r.m. Mainenti1  P.f.s. Teixeira2  F.p. Oliveira1  M. Vaisman2 
[1] ,Universidade Federal do Rio de Janeiro Faculdade de Medicina Departamento de Clínica Médica
关键词: Subclinical hypothyroidism;    Thyroid dysfunction;    Levothyroxine;    Ergospirometry;    Exercise physiology;   
DOI  :  10.1590/S0100-879X2010007500116
来源: SciELO
PDF
【 摘 要 】

Subclinical hypothyroidism (SH) patients present cardiopulmonary, vascular and muscle dysfunction, but there is no consensus about the benefits of levothyroxine (L-T4) intervention on cardiopulmonary performance during exercise. The aim of the present study was to investigate the effects of L-T4 on cardiopulmonary exercise reserve and recovery in SH patients. Twenty-three SH women, 44 (40-50) years old, were submitted to two ergospirometry tests, with an interval of 6 months of normalization of thyroid-stimulating hormone (TSH) levels (L-T4 replacement group) or simple observation (TSH = 6.90 μIU/mL; L-T4 = 1.02 ng/dL). Patients with TSH >10 μIU/mL were excluded from the study to assure that they would receive treatment in this later stage of SH. Twenty 30- to 57-year-old women with no thyroid dysfunction (TSH = 1.38 μIU/mL; L-T4 = 1.18 ng/dL) were also evaluated. At baseline, lower values of gas exchange ratio reserve (0.24 vs 0.30; P < 0.05) were found for SH patients. The treated group presented greater variation than the untreated group for pulmonary ventilation reserve (20.45 to 21.60 L/min; median variation = 5.2 vs 25.09 to 22.45 L/min; median variation = -4.75, respectively) and for gas exchange ratio reserve (0.19 to 0.27; median variation = 0.06 vs 0.28 to 0.18; median variation = -0.08, respectively). There were no relevant differences in cardiopulmonary recovery for either group at baseline or after follow-up. In the sample studied, L-T4 replacement improved exercise cardiopulmonary reserve, but no modification was found in recovery performance after exercise during this period of analysis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

【 预 览 】
附件列表
Files Size Format View
RO202005130078612ZK.pdf 471KB PDF download
  文献评价指标  
  下载次数:12次 浏览次数:13次