High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations

Brazilian Journal of Medical and Biological Research

D. Teixeira²  D. Vargens¹  A. Príncipe²  E. Oliveira²  A. Amorim²  M.j. Prata²  G. Suarez-kurtz¹ 

[1] ,Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)Porto,Portugal

关键词: African populations;    GSTM3 polymorphisms;    Multidimensional scaling analysis;    Pharmacogenetics;    Population diversity;   

DOI  :  10.1590/S0100-879X2010007500056

来源: SciELO

【 摘 要 】

A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3 *A/*B polymorphism.

【 授权许可】

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