Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals

Brazilian Journal of Medical and Biological Research

D.r.s. Souza²  M.a. Nakazone²  M.a.s. Pinhel²  R.m. Alvares²  A.c. Monaco²  A. Pinheiro²  C.f.d.c. Barros²  P.m. Cury¹  G.s. Cunrath¹  J.g. Netinho¹ 

[1] ,Faculdade de Medicina de São José do Rio Preto Departamento de Biologia Molecular

关键词: Apolipoprotein E;    Colorectal cancer;    Lipid profile;    Polymorphisms;   

DOI  :  10.1590/S0100-879X2009000500001

来源: SciELO

【 摘 要 】

We evaluated genetic variants of apolipoprotein E (APOE HhaI) and their association with serum lipids in colorectal cancer (CRC), together with eating habits and personal history. Eight-seven adults with CRC and 73 controls were studied. APOE*2 (rs7412) and APOE*4 (rs429358) were identified by polymerase chain reaction-restriction fragment length polymorphism. APOE gene polymorphisms were similar in both groups, but the ε4/ε4 genotype (6%) was present only in controls. The patients had reduced levels (mean ± SD) of total cholesterol and low-density lipoprotein cholesterol fraction (180.4 ± 49.5 and 116.1 ± 43.1 mg/dL, respectively) compared to controls (204.2 ± 55.6, P = 0.135 and 134.7 ± 50.8 mg/dL; P = 0.330, respectively) indicating that they were not statistically significant after the Bonferroni correction. The APOE*4 allele was associated with lower levels of total cholesterol, low- and high-density lipoprotein cholesterol fraction and increased levels of very low-density lipoprotein cholesterol fraction and triglycerides only among patients (P = 0.014). There was a positive correlation between the altered lipid profile and increased body mass indexes in both groups (P < 0.010). Moreover, a higher rate of hypertension and overweight was observed in controls (P < 0.002). In conclusion, the presence of the ε4/ε4 genotype only in controls may be due to a protective effect against CRC. Lower lipid profile values among patients, even those on lipid-rich diets associated with the APOE*4 allele, suggest alterations in the lipid synthesis and metabolism pathways in CRC.

【 授权许可】

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