期刊论文详细信息
Brazilian Journal of Medical and Biological Research
Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables
G.s. Macêdo2  C.l.p. Ferreira2  A. Menegaz1  V.c. Arantes1  R.v. Veloso1  E.m. Carneiro1  A.c. Boschero1  C.m.p. Oller Do Nascimento1  M.q. Latorraca2  M.h.g. Gomes-da-silva2 
[1] ,Universidade Federal de Mato Grosso Faculdade de Ciências Médicas Cuiabá MT ,Brasil
关键词: Low-protein diet;    Pregnancy;    Serum leptin;    Serum insulin;    Body adiposity;   
DOI  :  10.1590/S0100-879X2008000600014
来源: SciELO
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【 摘 要 】

During pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.

【 授权许可】

CC BY   
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