Pathogenesis of Salmonella-induced enteritis

Brazilian Journal of Medical and Biological Research

R.l. Santos²  R.m. Tsolis¹  A.j. Bäumler¹  L.g. Adams¹ 

[1] ,Universidade Federal de Minas Gerais Escola de Veterinária Departamento de Clínica e Cirurgia VeterináriasBelo Horizonte MG ,Brasil

关键词: Salmonella typhimurium;    Enteritis;    Diarrhea;    Salmonellosis;   

DOI  :  10.1590/S0100-879X2003000100002

来源: SciELO

【 摘 要 】

Infections with Salmonella serotypes are a major cause of food-borne diseases worldwide. Animal models other than the mouse have been employed for the study of nontyphoidal Salmonella infections because the murine model is not suitable for the study of Salmonella-induced diarrhea. The microbe has developed mechanisms to exploit the host cell machinery to its own purpose. Bacterial proteins delivered directly into the host cell cytosol cause cytoskeletal changes and interfere with host cell signaling pathways, which ultimately enhance disease manifestation. Recently, marked advances have been made in our understanding of the molecular interactions between Salmonella serotypes and their hosts. Here, we discuss the molecular basis of the pathogenesis of Salmonella-induced enteritis.

【 授权许可】

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