Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC

Brazilian Journal of Medical and Biological Research

M.c. Bayeux¹  A.t. Fernandes¹  M.a. Foglio¹  J.e. Carvalho¹ 

[1] ,Universidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas

关键词: Cordia curassavica;    Cordia verbenaceae;    Antiedematogenic;    Anti-inflammatory;    Medicinal plants;   

DOI  :  10.1590/S0100-879X2002001000017

来源: SciELO

【 摘 要 】

The species Cordia curassavica (Boraginaceae), known popularly as "erva baleeira", is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the edema by 45 and 48%, after 4 and 5 h, but the artemetin-enriched fraction (30, 100 and 300 mg/kg, po, N = 6) had no activity. The dichloromethane extract (300 and 1000 mg/kg, po, N = 6) also showed antinociceptive activity by reducing acetic acid-induced writhing in mice from 37.1 ± 2.28 (control) to 17.3 ± 1.34 and 13.2 ± 1.44, respectively, but had no activity in the hot-plate test.

【 授权许可】

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