Experimental myocardial hypertrophy induced by a minimally invasive ascending aorta coarctation

Brazilian Journal of Medical and Biological Research

A.s. Martins²  N.w. Aguilera²  B.b. Matsubara¹  E.a. Bregagnollo¹ 

[1] ,Universidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Cirurgia e Ortopedia

关键词: ventricular hypertrophy;    ventricular function;    experimental model;   

DOI  :  10.1590/S0100-879X2001000300017

来源: SciELO

【 摘 要 】

Ascending aorta coarctation was produced by a minimally invasive technique in rabbits. Animal mortality was 5%. Morphometric and hemodynamic parameters were evaluated. A parabiotically isolated heart model was used to assess the hemodynamic parameters. Left ventricular weight/body weight ratio and muscle area showed clear evidence of hypertrophy when compared to control. The hemodynamic changes in the isolated heart model suggested decreased diastolic and systolic function in the coarcted group. The present model produced hypertrophy with low mortality rates as a result of its less invasive nature.

【 授权许可】

CC BY   
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