期刊论文详细信息
Brazilian Journal of Medical and Biological Research
Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension
V.m.a. Farah1  E.d. Moreira1  M. Ushizima1  I.a. Cestari1  M.c. Irigoyen1  E.m. Krieger1 
[1] ,Universidade de São Paulo, São Paulo Faculdade de Medicina Hospital das Clínicas
关键词: baroreflex sensitivity;    losartan;    angiotensin II;    renal hypertension;   
DOI  :  10.1590/S0100-879X2000001200014
来源: SciELO
PDF
【 摘 要 】

To assess the role of angiotensin II in the sensitivity of the baroreflex control of heart rate (HR) in normotensive rats (N = 6) and chronically hypertensive rats (1K1C, 2 months, N = 7), reflex changes of HR were evaluated before and after (15 min) the administration of a selective angiotensin II receptor antagonist (losartan, 10 mg/kg, iv). Baseline values of mean arterial pressure (MAP) were higher in hypertensive rats (195 ± 6 mmHg) than in normotensive rats (110 ± 2 mmHg). Losartan administration promoted a decrease in MAP only in hypertensive rats (16%), with no changes in HR. During the control period, the sensitivity of the bradycardic and tachycardic responses to acute MAP changes were depressed in hypertensive rats (~70% and ~65%, respectively) and remained unchanged after losartan administration. Plasma renin activity was similar in the two groups. The present study demonstrates that acute blockade of AT1 receptors with losartan lowers the MAP in chronic renal hypertensive rats without reversal of baroreflex hyposensitivity, suggesting that the impairment of baroreflex control of HR is not dependent on an increased angiotensin II level.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

【 预 览 】
附件列表
Files Size Format View
RO202005130076631ZK.pdf 167KB PDF download
  文献评价指标  
  下载次数:2次 浏览次数:9次