Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin

Brazilian Journal of Medical and Biological Research

J.c. Santos¹  S. Jerez¹  M. Peral De Bruno¹  A. Coviello¹ 

[1] ,Fundación INELCO INSIBIO Facultad de Ciencias Naturales e Instituto Miguel LilloTucumán,Argentina

关键词: angiotensin-(1-7);    toad skin;    osmotic water permeability;    receptor subtypes;   

DOI  :  10.1590/S0100-879X2000000900018

来源: SciELO

【 摘 要 】

Angiotensin-(1-7) (Ang-(1-7)) increased osmotic water permeability in the isolated toad skin, a tissue with functional properties similar to those of the distal mammalian nephron. Concentrations of 0.1 to 10 µM were effective, with a peak at 20 min. This effect was similar in magnitude to that of frog skin angiotensin II (Ang II) and oxytocin but lower than that of human Ang II and arginine-vasotocin. The AT2 angiotensin receptor antagonist PD 123319 (1.0 µM) fully inhibited the response to 0.1 µM Ang-(1-7) but had no effect on the response to Ang II at the same concentration. The specific receptor antagonist of Ang-(1-7), A-779, was ineffective in blocking the response to Ang-(1-7) and to frog skin Ang II. The AT1 receptor subtype antagonist losartan, which blocked the response to frog skin Ang II, was ineffective in blocking the response to Ang-(1-7). The present results support the view of an antidiuretic action of Ang-(1-7) in the mammalian nephron.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License