Serum cytokines in patients with Brazilian pemphigus foliaceus (fogo selvagem)

Brazilian Journal of Medical and Biological Research

D.m. Zeoti¹  J.f.c. Figueiredo²  M.p.v. Chiossi¹  A.m.f. Roselino¹ 

[1],Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Clínica Médica

关键词: cytokines;    pemphigus;    pemphigus foliaceus;    fogo selvagem;    bullous dermatoses;   

DOI  :  10.1590/S0100-879X2000000900012

来源: SciELO

【 摘 要 】

Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a control group consisting of 10 healthy individuals were studied. Serum IL-2, IL-4, IL-5, IL-10, IL-12 and IFN-gamma were measured in the two groups by ELISA. The median concentration of IL-2 was lower in PF patients compared to the control group (0.45 and 9.50 pg/ml, respectively), as also was the concentration of IL-4 (0.26 and 10.16 pg/ml, respectively). The same was observed for IL-5 (7.94 and 15.74 pg/ml, respectively) and for IFN-gamma (5.90 and 8.58 pg/ml, respectively). For IL-10 and IL-12, higher concentrations were observed in PF compared to the control group (IL-10: 24.76 and 20.92; IL-12: 2.92 and 1.17 pg/ml, respectively). Considering the Th1/Th2 paradigm, it seems that a Th2 profile, mainly represented by IL-10, predominates in PF.

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