Alternative mitochondrial functions in cell physiopathology: beyond ATP production

Brazilian Journal of Medical and Biological Research

A.j. Kowaltowski¹ 

[1] ,Universidade Estadual de CampinasCampinas SP ,Brasil

关键词: mitochondrial permeability transition;    uncoupling proteins;    alternative oxidase;    cardioprotection;    free radicals;    aging;   

DOI  :  10.1590/S0100-879X2000000200014

来源: SciELO

【 摘 要 】

It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License