Study of urinary acidification in patients with idiopathic hypocitraturia

Brazilian Journal of Medical and Biological Research

N.c. Araújo¹  M.a.p. Rebelo¹ 

[1] ,Universidade do Estado do Rio de JaneiroRio de Janeiro RJ ,Brasil

关键词: urinary acidification;    hypocitraturia;    titratable acidity;    ammonium;    ammonium chloride load test;    lithiasis;   

DOI  :  10.1590/S0100-879X2000000200007

来源: SciELO

【 摘 要 】

Hypocitraturia (HCit) is one of the most remarkable features of renal tubular acidosis, but an acidification defect is not seen in the majority of hypocitraturic patients, whose disease is denoted idiopathic hypocitraturia. In order to assess the integrity of urinary acidification mechanisms in hypocitraturic idiopathic calcium stone formers, we studied two groups of patients, hypocitraturic (HCit, N = 21, 39.5 ± 11.5 years, 11 females and 10 males) and normocitraturic (NCit, N = 23, 40.2 ± 11.7 years, 16 females and 7 males) subjects, during a short ammonium chloride loading test lasting 8 h. During the baseline period HCit patients showed significantly higher levels of titratable acid (TA). After the administration of ammonium chloride, mean urinary pH (3rd to 8th hour) and TA and ammonium excretion did not differ significantly between groups. Conversely, during the first hour mean urinary pH was lower and TA and ammonium excretion was higher in HCit. The enhanced TA excretion by HCit during the baseline period and during the first hour suggests that the phosphate buffer mechanism is activated. The earlier response in ammonium excretion by HCit further supports other evidence that acidification mechanisms react promptly. The present results suggest that in the course of lithiasic disease, hypocitraturia coexists with subtle changes in the excretion of hydrogen ions in basal situations.

【 授权许可】

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