Brazilian Journal of Medical and Biological Research | |
Cardiovascular responses to microinjection of trans-(±)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats | |
B.h. Machado1  L.g.h. Bonagamba1  | |
[1] ,Universidade de São Paulo | |
关键词: trans-(±)-ACPD; L-glutamate; ionotropic receptors; excitatory amino acid receptors; neurotransmission; baroreflex; chloralose anesthesia; trans-(±)-1-amino-1; 3-cyclopentanedicarboxylic acid; | |
DOI : 10.1590/S0100-879X1998000400016 | |
来源: SciELO | |
【 摘 要 】
The changes in mean arterial pressure (MAP) and heart rate (HR) in response to the activation of metabotropic receptors in the nucleus tractus solitarii (NTS) with trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-(±)-ACPD) were evaluated in conscious and anesthetized Wistar, male rats weighing 240-260 g (N = 8). The responses obtained with trans-(±)-ACPD were compared with the responses to L-glutamate (1 nmol/100 nl), since in a previous study we showed that anesthesia converted a pressor response to L-glutamate microinjected into the NTS of conscious rats to a depressor response in the same rats under urethane or chloralose anesthesia. Microinjection of 3 doses of trans-(±)-ACPD (100, 500 and 1000 pmol/100 nl) produced a dose-dependent fall in MAP (range, -20 to -50 mmHg) and HR (range, -30 to -170 bpm) under both conscious and chloralose anesthesia conditions. These data indicate that the cardiovascular responses to the activation of metabotropic receptors by trans-(±)-ACPD are not affected by chloralose anesthesia while the cardiovascular responses to the activation of excitatory amino acid (EAA) receptors by L-glutamate are significantly altered
【 授权许可】
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