Role of Th1 and Th2 cells in autoimmune demyelinating disease

Brazilian Journal of Medical and Biological Research

L. Nagelkerken¹ 

[1] ,TNO Prevention and Health

关键词: multiple sclerosis;    experimental allergic encephalomyelitis;    cytokines;    glucocorticoids;    Th1 cells;    antigen-presenting cells;   

DOI  :  10.1590/S0100-879X1998000100007

来源: SciELO

【 摘 要 】

Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its functional characteristics, e.g., the production of interleukin-12. Therefore, modulation of APC might interfere with the development of Th1 type responses and as such be beneficial for MS and EAE. The potential of cytokines, in particular interleukin-10, and glucocorticoids to exert a selective effect on APC, and as a consequence to affect the Th1-Th2 balance in EAE, is discussed

【 授权许可】

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