Eosinophil-active chemokines: assessment of in vivo activity

Brazilian Journal of Medical and Biological Research

M.m. Teixeira¹ 

[1] ,Universidade Federal de Minas Gerais

关键词: eosinophils;    chemokines;    eotaxin;    MIP-1a;    chemokine receptors;   

DOI  :  10.1590/S0100-879X1998000100003

来源: SciELO

【 摘 要 】

The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1a induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1a. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo

【 授权许可】

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