Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models

Brazilian Journal of Medical and Biological Research

E.a. Del-bel¹  P.r. Oliveira²  J.a.c. Oliveira²  P.k. Mishra¹  P.c. Jobe¹  N. Garcia-cairasco² 

[1] ,Faculdade de Medicina de Ribeirão Preto

关键词: experimental epilepsy;    seizures;    forebrain;    brainstem;    pilocarpine;    pentylenetetrazol;    audiogenic seizures;    genetically epilepsy-prone rats;    GEPR;    nitric oxide;   

DOI  :  10.1590/S0100-879X1997000800010

来源: SciELO

【 摘 要 】

The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License