Does plasma ANP participate in natriuresis induced by a-MSH?

Brazilian Journal of Medical and Biological Research

D.l.w. Picanço-diniz¹  G. Ribeiro-oliveira¹  A.l.v. Favaretto¹  J. Gutkowska¹  S.m. Mccann¹  J. Antunes-rodrigues¹ 

关键词: a-MSH;    AV3V;    ANP;    natriuresis;    kaliuresis;    diuresis;   

DOI  :  10.1590/S0100-879X1997000400005

来源: SciELO

【 摘 要 】

a-Melanocyte-stimulating hormone (a-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of a-MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of a-MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of a-MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that a-MSH may be involved in a g-MSH-independent mechanism of regulation of hydromineral metabolism

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