Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention

Brazilian Journal of Medical and Biological Research

P.d. Picon¹  S.c. Gonçalves¹  M.v. Wainstein¹  A.f. Costa¹  C.v. Mengarda¹  R.p. Machado¹  G.l. Berlim¹  M. Edelweiss¹  M.i. Edelweiss¹  J.p. Ribeiro¹ 

关键词: endothelium;    histamine;    Russell's viper venom;    coronary artery disease;   

DOI  :  10.1590/S0100-879X1997000300017

来源: SciELO

【 摘 要 】

Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches

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